Benzodiazepine BLOG

Clobazam is a drug which is a benzodiazepine derivative. It is marketed under the brand names Frisium, Urbanol, and Onfi and has been used as an anxiolytic since 1975 and an anticonvulsant since 1984.

Clobazam is used with other medication to control seizures in adults and children 2 years of age and older who have Lennox-Gastaut syndrome (a disorder that causes seizures and often causes developmental delays). It works by decreasing abnormal electrical activity in the brain.

How To Use:

Clobazam is available in oral form only, due to its insolubility in water. Take this medication by mouth exactly as directed by your doctor. Do not increase your dose, use it more frequently or use it for a longer period of time than prescribed because this drug can be habit-forming. Also, if used for an extended period, do not suddenly stop using this drug without your doctor's approval. Over time, this drug may not work as well. Consult your doctor if this medication stops working well.

Side Effects:

Clobazam may cause side effects, some of which may be serious. Call your doctor immediately or get emergency medical treatment if you experience any of these symptoms:

    • Drowsiness
    • Tiredness
    • Problems with coordination
    • Difficulty speaking or swallowing
    • Drooling
    • Vomiting
    • Change in appetite
    • Constipation
    • Difficulty, painful and frequent urination
    • Difficulty breathing
    • Rashes
    • Hives
    • Peeling or blistering skin
    • Fever
In the unlikely event you have a serious allergic reaction to this drug, seek immediate medical attention. Symptoms of a serious allergic reaction include rash, itching, swelling, severe dizziness and trouble breathing.


Clobazam should be used with great care in patients with the following disorders:
    • Myasthenia gravis
    • Sleep apnea
    • Severe liver diseases such as cirrhosis and hepatitis
    • Respiratory problems, including hypoventilation
There is now a new quantitative drug test designed to monitor clobazam and its primary active metabolite, desmethylclobazam. It is a fully validated quantitative procedure with a detection limit of 10 ng/mL for both analytes. The laboratory test utilizes a state of the art high-performance liquid chromatography-tandem mass spectrometry technique.